Recording from axons
-Axonal Propagation of Simple and Complex Spikes in Cerebellar Purkinje Neurons J. Neurosci., 25(2):454-463;
-Determinants of Action Potential Propagation in Cerebellar Purkinje Cell Axons
J. Neurosci., 25(2):464-472 (Mike Häusser's lab)
Amazing technique! They performed simultaneous measurements of action potentials at soma of Purkinje Cells and their axon to quantify the reliability of axnal spike propagation. If a cell spikes regularly, the axonal propagation is reliable even when the frequency exceeds 200 Hz. Interestingly, complex spike pattern such as bursts associated with CF activtion causes unreliable propagation. The reliability is determined by inter-spik-interval (for <2ms ISI, the second one is often skipped) and membrane voltage.
-Determinants of Action Potential Propagation in Cerebellar Purkinje Cell Axons
J. Neurosci., 25(2):464-472 (Mike Häusser's lab)
Amazing technique! They performed simultaneous measurements of action potentials at soma of Purkinje Cells and their axon to quantify the reliability of axnal spike propagation. If a cell spikes regularly, the axonal propagation is reliable even when the frequency exceeds 200 Hz. Interestingly, complex spike pattern such as bursts associated with CF activtion causes unreliable propagation. The reliability is determined by inter-spik-interval (for <2ms ISI, the second one is often skipped) and membrane voltage.
posted by Ryohei at 2:09 PM
<< Home